Technological developments and societal changes, impacting our environment under the key term “Digital Transformation”, led to digital approaches making an important contribution to supporting communication, collaboration, information acquisition and interactions between stakeholders, thereby enabling the development of innovative business models. Artificial intelligence, as an area of computer science, offers concepts that have now become feasible as applications rely on technological advances in the domains infrastructure, communication or cloud and offer promising potentials in the realization of digital transformation activities. The lecture also introduces results of experiments run in a university setting, so that the interrelations between innovation, digital transformation, and artificial intelligence during realization of selected scenarios are illustrated.